Serum Interleukin-34 in Psoriatic arthritis patients and its correlation with disease 1 activity, and subclinical atherosclerosis

Abstract Background Psoriatic arthritis (PsA) is a chronic multi-domains autoimmune inflammatory disorder. Patients with PsA have significant prevalence of cardiovascular affection. Upregulated Interleukin-34 (IL-34) has been seen in many disorders, and also atherosclerotic plaques. The aim this observational case–control study was to evaluate the serum levels il-34 patients correlate between its level disease activity, subclinical Results In study, there were 70 healthy volunteers, 43 on Methotrexate, 6 sulfasalazine, while 40 biological therapy either monotherapy or combination DMARDs. There differences controls ESR, high sensitivity-CRP, total lipid profile, IL-34 ( p < 0.05) no regarding Echo ECG results. Also, we found that elevation DAPSA score, hs-CRP, IL-34, cIMT active when compared them inactive patients. had positive correlations r = 0.654, 0.579, 0.658 respectively). Conclusion Serum interleukin-34 an important marker as elevated correlated activity